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Reproduction as a Characteristic of Life, Lecture notes of Anatomy

The characteristics of life, including reproduction, response to the environment, regulation, order, evolutionary adaptation, energy processing, growth and development. It also explains the two kinds of reproduction, asexual and sexual, and the process of meiosis. examples of organisms that reproduce asexually and sexually, and how meiosis produces sex cells. It also describes the stages of meiosis.

Typology: Lecture notes

2019/2020

Available from 05/28/2022

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LESSON 1: REPRODUCTION AS A CHARACTERISTIC OF LIFE
How do we know that it is an inanimate object?
CHARACTERISTICS OF LIFE:
REPRODUCTION an object or organism is considered a living if it has the ability to reproduce
on its own, thus implying a continued existence of the organism’s population.
All living organisms, from a single-celled amoeba to a 72 trillion-celled human, have an innate
drive not simply a desire-to reproduce
RESPONSE TO THE ENVIRONMENT organisms respond to diverse stimuli.
e.g. Plants can bend toward a source of light, climb fences and walls or respond to touch
(Mimosa Pudica or makahiya plant).
e.g. Tiny bacteria moving toward or away from chemicals (chemotaxis) or light
(phototaxis).
REGULATION (Adaptation) the ability to self-regulate. Even smallest organisms are complex
and require multiple regulatory mechanisms to coordinate internal functions, respond to stimuli,
and cope with environmental stresses. Two examples of internal functions regulated in
organisms are nutrient transport and blood flow. Organs (groups of tissues working together)
perform specific functions, such a carrying oxygen throughout the body, removing wastes,
delivering nutrients to every cell and cooling the body.
e.g. Sweating when temperature is high and frequent urinating when its cold.
ORDER organisms are highly organized, coordinated structures that consist of one or more
cells. Even very simple, single-celled organisms are remarkably complex: inside each cell, atoms
make up molecules, these in turn make up cell organelles and other cellular inclusions.
e.g. A toad (multicellular organism): similar cells form tissues, tissues in turn collaborate
to create organs (body structures with a distinct functions). Organs work together to form organ
systems (digestive system, reproductive system, respiratory system, integumentary system,
skeletal system, muscular system, etc.).
EVOLUTIONARY ADAPTATION a biological mechanism by which organisms adjust to new
environments or to changes in their current environment.
e.g. Biological adaptation there is an alteration of the body functions.
People living at high altitudes such as Tibet. Tibetans thrive to altitudes where oxygen
level is 40% lower that at sea level. Breathing air that thin would cause most people to get sick,
but Tibetans’ bodies have evolved changes in their body chemistry. They seemed to have
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LESSON 1: REPRODUCTION AS A CHARACTERISTIC OF LIFE

How do we know that it is an inanimate object?

CHARACTERISTICS OF LIFE:

  • REPRODUCTION – an object or organism is considered a living if it has the ability to reproduce on its own, thus implying a continued existence of the organism’s population.
  • All living organisms, from a single-celled amoeba to a 72 trillion-celled human, have an innate drive – not simply a desire-to reproduce
  • RESPONSE TO THE ENVIRONMENT – organisms respond to diverse stimuli. e.g. Plants can bend toward a source of light, climb fences and walls or respond to touch (Mimosa Pudica or makahiya plant). e.g. Tiny bacteria moving toward or away from chemicals (chemotaxis) or light (phototaxis).
  • REGULATION (Adaptation) – the ability to self-regulate. Even smallest organisms are complex and require multiple regulatory mechanisms to coordinate internal functions, respond to stimuli, and cope with environmental stresses. Two examples of internal functions regulated in organisms are nutrient transport and blood flow. Organs (groups of tissues working together) perform specific functions, such a carrying oxygen throughout the body, removing wastes, delivering nutrients to every cell and cooling the body. e.g. Sweating when temperature is high and frequent urinating when it’s cold.
  • ORDER – organisms are highly organized, coordinated structures that consist of one or more cells. Even very simple, single-celled organisms are remarkably complex: inside each cell, atoms make up molecules, these in turn make up cell organelles and other cellular inclusions. e.g. A toad (multicellular organism): similar cells form tissues, tissues in turn collaborate to create organs (body structures with a distinct functions). Organs work together to form organ systems (digestive system, reproductive system, respiratory system, integumentary system, skeletal system, muscular system, etc.).
  • EVOLUTIONARY ADAPTATION – a biological mechanism by which organisms adjust to new environments or to changes in their current environment. e.g. Biological adaptation – there is an alteration of the body functions. People living at high altitudes such as Tibet. Tibetans thrive to altitudes where oxygen level is 40% lower that at sea level. Breathing air that thin would cause most people to get sick, but Tibetans’ bodies have evolved changes in their body chemistry. They seemed to have

evolved genetic mutations that allow them to use oxygen far more efficiently without the need for extra hemoglobin (a protein that transport oxygen in the blood). e.g. Behavioral adaptation – Emperor penguins in Antarctica crowd together to share their warmth in the middle of the winter.

  • ENERGY PROCESSING – all organisms use a source of energy for their metabolic activities. Some organisms capture energy from the sun and convert it into chemical energy in food (photosynthesis); others use chemical energy in molecules they take in as food (cellular respiration). Remember! Energy can only be transformed, but can never be created nor destroyed.
  • GROWTH & DEVELOPMENT – organisms grow and develop following specific instructions coded for by their genes. These genes provide instructions that will direct cellular growth and development, ensuring that a species’ young will grow up to exhibit many of the same characteristics as its parents.

KINDS OF REPRODUCTION:

  • ASEXUAL – “without sex” (sex in this context pertains to intercourse). The simplest and the most primitive method of reproduction, involves a single parent and produces a clone, an organism that is genetically identical to the parent (A single cell will be divided into 2 identical daughter cells – “ mitosis ”). A parent passes all of its genetic material to the next generation. All prokaryotic and some eukaryotic organisms reproduce asexually. Prokaryote – a single-celled organism that lacks a cell nucleus and a membrane-like organelles (falls in the domains of bacteria and archaea). Eukaryote – (animals – starfish, jellyfish, Komodo dragon , ants, bees, plants, fungi- mushrooms, yeasts, molds, rusts, and protists- algae, amoebas, slime molds ) organism whose cells have a nucleus enclosed within a nuclear envelope. Komodo dragon – Parthenogenesis “virgin birth” which an egg can develop into an embryo without being fertilized by a sperm. Starfish – ‘Fragmentation’ body breaks into several fragments that later develop into complete organisms. Jellyfish (Polyps) – ‘Budding’ organisms reproduce by having new individuals split off from existing ones. Advantages of Asexual Reproduction:
  • Independently done
  • Capable of creating a large population in a relatively short time.
  • All asexual organisms are equally successful in the constant environment.
  • The centrioles are now at opposite poles of the cell with the mitotic spindle fibres extending from them.
  • The mitotic spindle fibres attach to each of the sister chromatids. 4. Anaphase:
  • The sister chromatids are then pulled apart by the mitotic spindle which pulls one chromatid to one pole and the other chromatid to the opposite pole. 5. Telophase:
  • At each pole of the cell a full set of chromosomes gather together.
  • A membrane forms around each set of chromosomes to create two new nuclei.
  • The single cell then pinches in the middle to form two separate daughter cells each containing a full set of chromosomes within a nucleus. This process is known as cytokinesis.
  • SEXUAL – Sexual reproduction occurs when the sperm from the male parent fertilizes an egg from the female parent, producing an offspring that is genetically different from both parents (unless for identical twins). Fraternal twins develop from two eggs that have been fertilized from two separate sperms. They are otherwise known as dizygotic or non-identical twins. Maternal twins or identical twins , on the other hand, are twins that develop from one fertilized egg that then splits into two forming two embryos.
  • Organisms are genetically diverse because of sexual reproduction. Sexual reproduction begins with sperm and egg cells, which are produced through a process called “ meiosis ”. These cells are referred to as haploid ( 23 chromosomes, each of which a one of a chromosome pair that exists in diploid cells) because they contain half of the number of chromosomes as the parent. In sexual reproduction, a haploid sperm from the male parent fertilizes the haploid egg from the female parent to produce what is called a diploid zygote.
  • Zygote is the technical term for a fertilized egg. The diploid (23 pairs of chromosomes) number of chromosomes is the normal number of chromosomes found in all of the regular cells of an organism. The zygote grows and develops into a new organism. It is genetically different from both parents because half of its chromosomes came from the male parent and half of the chromosomes came from the female parent, giving it a unique combination of genes.
  • Sexual reproduction occurs in both plants and animals. Among plants it is used most notably by flowering plants. The pollen grains of flowers contain the sperm. The vase-shaped female reproductive organ in the base of the flower, or the pistil, contains the eggs. When the pollen grains land on top of the pistil, they make a pathway to the eggs. Each zygote develops into a seed that, when in soil, can grow into a new plant.
  • Sexual reproduction occurs in a variety of ways in animals. In some species, such as fish, the male releases sperm over the eggs after the female has laid them. In other species, such as birds and most mammals including human beings, the male releases sperm into the female reproductive tract. Some animals, such as earthworms, are hermaphroditic; they possess male and female sexual organs and can produce both sperm and eggs. They mate with other earthworms, however, to produce genetically diverse worms.

WHAT IS MEIOSIS?

Meiosis is a process where a single cell divides twice to produce four cells containing half the original amount of genetic information. These cells are our sex cells – sperm in males, eggs in females.

  • During meiosis one cell divides twice to form four daughter cells.
  • These four daughter cells only have half the number of chromosomes of the parent cell – they are haploid.
  • Meiosis produces our sex cells or gametes (eggs in females and sperm in males).
  • A membrane forms around each set of chromosomes to create two new nuclei.
  • The single cell then pinches in the middle to form two separate daughter cells each containing a full set of chromosomes within a nucleus. This process is known as cytokinesis. **MEIOSIS II
  1. Prophase II:**
  • Now there are two daughter cells, each with 23 chromosomes (23 pairs of chromatids).
  • In each of the two daughter cells the chromosomes condense again into visible X-shaped structures that can be easily seen under a microscope.
  • The membrane around the nucleus in each daughter cell dissolves away releasing the chromosomes.
  • The centrioles duplicate.
  • The meiotic spindle forms again. 7. Metaphase II:
  • In each of the two daughter cells the chromosomes (pair of sister chromatids) line up end-to-end along the equator of the cell.
  • The centrioles are now at opposites poles in each of the daughter cells.
  • Meiotic spindle fibres at each pole of the cell attach to each of the sister chromatids. 8. Anaphase II:
  • The sister chromatids are then pulled to opposite poles due to the action of the meiotic spindle.
  • The separated chromatids are now individual chromosomes. 9. Telophase II and cytokinesis:
  • The chromosomes complete their move to the opposite poles of the cell.
  • At each pole of the cell a full set of chromosomes gather together.
  • A membrane forms around each set of chromosomes to create two new cell nuclei.
  • This is the last phase of meiosis; however, cell division is not complete without another round of cytokinesis.
  • Once cytokinesis is complete there are four granddaughter cells, each with half a set of chromosomes (haploid): o in males, these four cells are all sperm cells o in females, one of the cells is an egg cell while the other three are polar bodies (small cells that do not develop into eggs).

CLONING - Cloning is a technique, scientists use to create exact genetic replicas of genes, cells, or

animals.

  • Some clones already exist in nature. Single-celled organisms like bacteria make exact copies of themselves each time they reproduce. In humans, identical twins are similar to clones. They share almost the exact same genes. Identical twins are created when a fertilized egg splits in two. Scientists also make clones in the lab. They often clone genes in order to study and better understand them. To clone a gene, researchers take DNA from a living creature and insert it into

LESSON 2: HORMONES

WHAT IS HORMONE?

  • Chemical signals that secreted into the circulatory system and communicate regulatory messages within the body.
  • Hormones and other signaling molecules reach all parts of the body and bind to target receptors, triggering specific response pathways (only target cells are equipped to respond)
  • Hormones are the ones able to communicate life processes althroughout organisms. TWO SYSTEMS THAT COORDINATE COMMUNICATION THROUGHOUT THE BODY
  1. Endocrine System – secretes hormones that coordinate slower than longer-acting responses including reproduction, development, energy metabolism, growth and behavior.
  2. Nervous System – conveys high-speed electrical signals along specialized cells called neurons; these signals regulate other cells. TYPES OF SECRETED SIGNALING MOLECULES: Secreted chemical signals include;
  • Hormones (endocrine signals) – are secreted into extracellular fluids and travel via bloodstream. Endocrine glands are ductless and secrete hormones directly into surrounding fluid. Hormones mediate responses to environmental stimuli and regulate growth, development and reproduction. Exocrine glands have ducts and secrete substances onto body surfaces or body cavities (e.g. tear ducts) Examples of Intercellular Communication by secreted molecules:
  1. Endocrine Signaling -
  2. Paracrine Signaling
  3. Autocrine Signaling
  4. Synaptic Signaling
  5. Neuroendocrine Signaling
  • Local regulators ( short distance chemical signals ) - are chemical signals that travel over short distances by diffusion. This helps regulate blood pressure, nervous system function, and reproduction. Paracrine – signals act on cells near the secreting cell. Autocrine – signals act on the secreting cell itself.
  • Neurotransmitters – neurons (nerve cells) contact target cells at synapses. At synapses , neurons often secrete chemical signals, called neurotransmitters that diffuse a short distance bind to receptors on the target cell Neurotransmitters play a role in sensation, memory, cognition and movement.
  • Neurohormones – are a class of hormones that originate from neurons in the brain and diffuse through the bloodstream.
  • Pheromones – are chemical signals that are released from the body and used to communicate with other individuals n the species. These mark trails to food sources, warn of predators and attract potential mates. CHEMICAL CLASSES OF HORMONES
  1. Polypeptides (proteins and peptides)
  2. Amines - derived from amino acids
  3. Steroid hormones – derived from cholesterol or fats , examples are testosterone and progesterone. Note: both Polypeptides and Amines are water-soluble: do not pass through the cell membrane, while Steroids are lipid-soluble: easily passed through cell membrane. The solubility of a hormone correlates with the location of receptors inside or on the surface of target cells. Lipid-soluble hormone receptor activation: Nuclear hormone receptors are activated by a lipid-soluble hormone such as estrogen, binding to them inside the cell. Lipid-soluble hormones can cross the plasma membrane.

Signal Transduction Pathway: Signaling by any of these hormones involves three key events:

  1. Reception
  2. Signal Transduction
  3. Response Binding of a hormone to its receptor initiates a signal transduction pathway leading to responses in the cytoplasm, enzyme activation, or a change in gene expression. Multiple Effects of Hormones:
  • The same hormone may have different effects on target cells that have;
  1. Different receptors for the hormone.
  2. Different signal transduction pathways.
  3. Different proteins for carrying out the response.
  • A hormone can also have different effects in different species.

The endocrine and nervous systems act individually and together in regulating in animal physiology. Signals from the b=nervous system initiate and regulate endocrine signals. Feedback mechanisms regulate biological systems, feedback mechanisms allow biological processes to self-regulate.

  • Negative feedback means that as more of a product accumulates, the process that creates it slows and less of the product is produced.
  • Positive feedback means that as more of a product accumulates, the process that creates it speeds up and more of the product is produced.

TROPIC HORMONES – regulates the function of endocrine cells and glands. The four

strictly tropic hormones are:

1. Thyroid-stimulating hormone (TSH)

2. Follicle-stimulating hormone (FSH)

3. Luteinizing hormone (LH)

4. Adrenocorticotropic hormone (ACTH)

Note: for Human Reproduction we will focus in these three hormones (TSH, FSH

& LH).

NONTROPIC HORMONES – target nonendocrine tissues. Non-tropic hormones produce

by the anterior pituitary are:

1. Prolactin (PRL) – stimulates lactation in mammals but has diverse

effects in different vertebrates.

2. Melanocyte-stimulating hormone (MSH) – influences skin

pigmentation in some vertebrates and fat metabolism in mammals.

GONADAL SEX HORMONES

Gonads – testes and ovaries, produce most of the sex hormones: androgens,

estrogens and progestins. All three sex hormones are found in both males and

females but in different amounts.

Testes primarily synthesize androgens, mainly testosterone which

simulate development and maintenance of the male reproductive system

and male secondary sex characteristics.

Testosterone causes an increase in muscle and bone mass and is often

as a supplement to cause muscle growth, which carries health risks.

Estrogens, made in ovary most importantly estradiol are responsible for

maintenance of the female reproductive system and the development of

female secondary sex characteristics.

In mammals, progestins , which include progesterone are primarily

involves in preparing and maintaining the uterus.

Synthesis of the sex hormones is controlled by FSH and LH from the

anterior pituitary.

The interplay of tropic and sex hormones regulates mammalian reproduction.

  • Human reproduction is coordinated by hormones from hypothalamus , anterior pituitary gland and gonads.
  • Gonadotropin-releasing hormone (GnRH) is secreted by the hypothalamus and directs the release of FSH and LH from the anterior pituitary.
  • FSH and LH regulate processes in the gonads and the production of sex hormones. Sex hormones are androgens, estrogens and progesterone. Sex hormones regulate: 1. The development of primary sex characteristics during embryogenesis. 2. The development of secondary sex characteristics at puberty. 3. Sexual behavior and sex drive. HORMONAL CONTROL OF THE MALE REPRODUCTIVE SYSTEM
  • FSH promotes the activity of Sertoli cells , which nourish developing sperm and are located within the seminiferous tubules of the scrotum.
  • LH regulates Leydig cells , which secrete testosterone and other androgen hormones, which in turn promote spermatogenesis-formation of sperms.
  • Testosterone regulates the production of GnRH, FSH and LH through negative feedback mechanisms.