QUESTION 01
Describe the experimental technology used by unscrupulous scientists in creating ‘genetic
doubles’ of people with transplant needs. Explain the science behind the procedure
Kevin and his colleagues are working on the genes for minor histocompatibility antigens. They
're moving them from a specific chromosome in one cell and sticking them into the same
location on the same chromosome in another cell, particularly the short arm of chromosome six
from one cell to another, from one species to another. They have created some kind of chimera
with these apes’ called bonobos. He was creating a custom - designing perfect organ transplant
source for a specific individual. Kevin Marshal gets a bone - marrow sample (preferably a stem
cell) from a client then isolates a cell preparing to divide so that the chromosomes are
condensed. Then, he adds his secret transponase he discovered seven years ago that catalyzes
the homologous transposition or crossing over of the short arms of chromosome six to a client
's cell that is preparing to divide. By detaching short arms of the chromosomes, he halts the
crossing over. After that, he extracts the detached part of the chromosome arm. After that,
Melanie takes care of the double 's birth through in vitro fertilization techniques using the
Bonobo 's egg and sperm. She’s using the same techniques that were developed to increase the
fertility of captive mountain gorillas. Kevin and Melanie have to coordinate because Melanie
will be Kevin 's signal in proceeding to the next step. When she delivers the ready to divide
zygote, Kevin repeats exactly the same procedure to the zygote that he 'd just done with the
client 's cell. After removing the bonobo short arms, he injects the client 's short arms into the
zygote. Through the help of his secret transponase the detached client 's short arm of
chromosome six will hook right up exactly where they are supposed to be. Then they will put
the zygote into a female bonobo in order for the client 's double to born. After years, if the
organs are mature enough to be transplanted, they will carry out the operation and the
procedure called xenograft where in an animal organ or tissue dial is transplanted into a human.
The bonobo double will have the same organs to the client that is why there is no rejection
when they will transplant the organ from the double to the client.
The genetic double experiment is a biological program that introduces human genome to
bonobo to become transgenic animals as reservoirs of organs which can, with a little
manipulation, be used in humans. It started with Kevin Marshall 's discovery of the
homologous transposition in the chromosome 6 where it is the major gene for
histocompatibility complex. The procedure starts with isolating the short arms of chromosome
6 and other minor histocompatibility antigens in the human patient ' s stem cells before crossing
over happens. It uses tranponase to transfer the short arms and inserting it in the developing
bonobo zygote ' s chromosome. The bonobo ages and become the immunological double of the
patient which they have compatible organs to transfer without any rejection reaction at all.
QUESTION 02
Relate circumstances which threatened the well-placed scam of exposure. Relate what the
culprits did to avert disaster.
