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Lymphatic and Immune system (Anatomy and Physiology), Lecture notes of Anatomy

Brief lecture notes of Lymphatic and immune system

Typology: Lecture notes

2021/2022

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OUTLINE:
I. LYMPHATIC SYSTEM
i. Origins Of The Lymphatic System:
Capillary Beds
ii. Lymphatic Structure
a. Lymph
b. Lymphatic Vessels
c. Lymphoid Organs
iii. What Does Lymphatic System Do?
II. IMMUNE SYSTEM
i. Innate Defense System
a. External Barricade
b. Internal Innate Defenses
c. Inflammatory Response
ii. Adaptive Defense System
a. Humoral Immunity
b. Cell-Mediated Immunity
LYMPHATIC SYSTEM
- A security line; checkpoints – has the ability to take
care of small infections on the spot
- It takes up some extra fluid, and runs a background
check
- Quietly plays a vital supporting role to both
cardiovascular and immune systems
It maintains homeostasis by eventually returning most
of the fluid that has been diverted back into the blood
ORIGINS OF THE LYMPHATIC SYSTEM: CAPILLARY BEDS
- Capillary beds where the capillaries carry blood
from arterioles and feed blood into venules
oWhere transfer of nutrients and waste takes
place
- As blood plasma force plasma out of the arteriole
end of the capillaries and into the interstitial fluid
between the cells. And most fluid gets drawn right
back into the capillaries on the venous end through
OSMOTIC PRESSURE
THE LYMPHATIC SYSTEM STRUCTURE
- Consists of 3 main parts:
oLymph
oLymphatic vessels
oLymphoid organs
LYMPH
- A watery fluid that flows through your lymphatic
system.
- This solution does nor contain RBC, which remain in
the closed circulatory loop because they are too
large to pass through capillary membranes.
- Starts out as blood plasma, that’s forced out of the
capillaries, way down in the capillary beds, where
there is leakage
LYMPHATIC VESSELS
LYMPHATIC VESSELS
- A network of lymphatic vessels that help reabsorbs
the fluid that are left behind
- 17 out of 20 liters is taken back up by the venous
end
- Other 3 liters becomes the lymph
- Lymphatic capillary
oAll over the body, but notably absent from
bones, bone marrow, teeth, and the CNS
oLoosely overlapping, endothelial cells,
forming flaplike mini valves that only open
in one direction
Lymph flows through larger lymphatic vessels
(LYMPH NODES) to collecting vessels
then to large trunks (LYMPH TRUNK)
and, into one of two big ducts ( LYMPH DUCT) that
feed back into the lowest pressure area of the
circulatory system
RIGHT LYMPAPHATIC DUCT drains all the lymph
collected from the upper right area of the torso, arm,
head and thorax, and feeds them all into the internal
jugular vein
LARGER THORACIC DUCT – takes lymph from the rest of
the body and dumps it into the subclavian vein
- lymphatic vessels operate under very low pressure,
have a series of valves that prevent backflow, and
are helped along a bit by smooth muscle in the
vessel walls that keep the fluid moving
LYMPHATIC NODES
-LYMPH NODES Checkpoints that monitor and
cleanse the lymph nodes, as it filters through
- Main lymphoid organs
- Regular inspection by lymphocytes
- Depending on what microorganism they find in the
fluid, lymphocytes can trigger the release of
macrophages or activate the general immune
system
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OUTLINE:

I. LYMPHATIC SYSTEM

i. Origins Of The Lymphatic System: Capillary Beds ii. Lymphatic Structure a. Lymph b. Lymphatic Vessels c. Lymphoid Organs iii. What Does Lymphatic System Do? II. IMMUNE SYSTEM i. Innate Defense System a. External Barricade b. Internal Innate Defenses c. Inflammatory Response ii. Adaptive Defense System a. Humoral Immunity b. Cell-Mediated Immunity LYMPHATIC SYSTEM

  • A security line; checkpoints – has the ability to take care of small infections on the spot
  • It takes up some extra fluid, and runs a background check
  • Quietly plays a vital supporting role to both cardiovascular and immune systems It maintains homeostasis by eventually returning most of the fluid that has been diverted back into the blood ORIGINS OF THE LYMPHATIC SYSTEM: CAPILLARY BEDS
  • Capillary beds – where the capillaries carry blood from arterioles and feed blood into venules o Where transfer of nutrients and waste takes place
  • As blood plasma force plasma out of the arteriole end of the capillaries and into the interstitial fluid between the cells. And most fluid gets drawn right back into the capillaries on the venous end through OSMOTIC PRESSURE THE LYMPHATIC SYSTEM STRUCTURE
  • Consists of 3 main parts: o Lymph o Lymphatic vessels o Lymphoid organs LYMPH
  • A watery fluid that flows through your lymphatic system. - This solution does nor contain RBC, which remain in the closed circulatory loop because they are too large to pass through capillary membranes. - Starts out as blood plasma, that’s forced out of the capillaries, way down in the capillary beds, where there is leakage LYMPHATIC VESSELS LYMPHATIC VESSELS - A network of lymphatic vessels that help reabsorbs the fluid that are left behind - 17 out of 20 liters is taken back up by the venous end - Other 3 liters becomes the lymph - Lymphatic capillary o All over the body, but notably absent from bones, bone marrow, teeth, and the CNS o Loosely overlapping, endothelial cells, forming flaplike mini valves that only open in one direction  Lymph flows through larger lymphatic vessels ( LYMPH NODES ) to collecting vessels  then to large trunks ( LYMPH TRUNK )  and, into one of two big ducts ( LYMPH DUCT ) that feed back into the lowest pressure area of the circulatory system RIGHT LYMPAPHATIC DUCT – drains all the lymph collected from the upper right area of the torso, arm, head and thorax, and feeds them all into the internal jugular vein LARGER THORACIC DUCT – takes lymph from the rest of the body and dumps it into the subclavian vein - lymphatic vessels operate under very low pressure, have a series of valves that prevent backflow, and are helped along a bit by smooth muscle in the vessel walls that keep the fluid moving LYMPHATIC NODES - LYMPH NODES – Checkpoints that monitor and cleanse the lymph nodes, as it filters through - Main lymphoid organs - Regular inspection by lymphocytes - Depending on what microorganism they find in the fluid, lymphocytes can trigger the release of macrophages or activate the general immune system
  • Lymphocytes are found and mature in the loose reticular connective tissue that makes up a larger part of the nodes and most of the lymphoid organs
  • Overwhelmed nodes may become inflamed; often an early diagnostic sign of disease or infection LYMPHOID ORGANS
  • Spleen and Thymus o Provide a nursery for maturing immune cells called lymphocytes
  • Adenoids
  • Tonsils MUCOSA-ASSOCIATED LYMPHOID TISSUES (MALTs)
  • Collections of lymphoid tissue embedding in the tissues lining the respiratory and digestive tracts. Where MALTs are found:
  • Tonsils o Try to remove any pathogens before they can enter the GI tract or lungs
  • Peyer’s patches o Distal portion of the small intestine providing another checkpoint along the GI tract
  • Appendix o Contains a bunch of lymphoid tissue to destroy any remaining bacteria before it can breach the interstitial wall during absorption WHAT DOES THE LYMPHATIC SYSTEM DO?
  • Recovering 3 liters of blood fluid per day, more than half of the total blood volume
  • without recovering it, it can cause serious drop of blood pressure, little to no oxygen delivery or waste pick up
  • EDEMA – swelling that can constrain blood flow
  • Plays a key role in the function of the immune system

IMMUNE SYSTEM

Detect, deflect, destroy INNATE, OR NONSPECIFIC, DEFENSE SYSTEM

  • First line of defense
  • External barricades – skin, mucous membranes
  • Internal defenses – phagocytes, antimicrobial proteins, attack cells
  • Uses an arsenal of physical and chemical barriers, killer cells, and fever to keep the body healthy EXTERNAL BARRICADES SKIN AS A PHYSICAL BARRIER o Simple physical barrier o As long as that keratinized epithelial membrane doesn’t get torn or busted up too much MUCOUS MEMBRANES o Handy physical barrier o They line any cavity that opens up into the external (respiratory, digestive urinary, reproductive) CHEMICAL DEFENSES INCLUDE:
  • Acid from skin, stomach, and vaginal secretions
  • Mucin that forms mucus in the respiratory and digestive passageways
  • Enzymes found in saliva, mucus, and eye fluid that fight bacteria
  • Defensins or antimicrobial proteins
  • Other chemicals found in sweat that destroy bacteria INTERNAL INNATE DEFENSES - Causing fever, releasing chemical signals, causing inflammation PHAGOCYTES: NEUTROPHILS AND MACROPHAGES
  • To eat
  • Chase invaders NEUTROPHILS
  • Self-destruct after devouring a pathogen

HOW B CELLS IDENTIFY ANTIGENS

Antigens – invader from the outside world

  • act as flags that get the adaptive immune system riled up B lymphocyte – humoral response
  • mature in bone marrow
  • as it matures, it develops the ability to determine friend from foe, developing both immunocompetence – recognizing and binding to a particular antigen and self-tolerance
  • once fully matured, it displays at least 10, special protein receptors on its surface – membrane-bound antibodies
  • the more unique antibodies your lymphocytes have, the more likely it is that one will eventually find, to bind, and mark a particular antigen
  • Once matured, B cells will colonize or seed the secondary lymphoid organs. They won’t be activated until they find their perfect enemy match B CELLS BECOME EFFECTOR CELLS & MEMORY CELLS  When B cell finally bumps into an antigen it has antibodies for, and recognizes it, and binds to it. Humoral immune response is summoned.  Once activated, B cells starts cloning itself, all of it will fight that one particular antigen.
  • These clones become active fighters or effector cells.
  • A few will become long-lived memory cells that preserve the genetic code for that specific, successful antibody. o The first exposure to an antigen spurs a primary immune response that may take several days to peak. But, if a person is re- exposed to the same antigen in the future, a secondary response occurs much faster because those old memory B cells are still on alert and ready to fight back
  • The effector or plasma cells are packed with extra amount of rough endoplasmic reticulum, which acts as an antibody factory. o Can mass-produce the same antibodies into the humor at a rate of 2000 antibodies per second for 4-5 days until they die o Opsonization - tag foreign pathogens for elimination

HOW ANIBODIES FIGHT ANTIGENS

Neutralization – most effective and common strategies, where antibodies physically block the binding sites on antigens, so they can’t hook up to your tissues.

  • Agglutination – antibodies binding to multiple antigens at the same time. Result to clumping… Antibodies are also ringing a chemical signal, calling in phagocytes from the innate immune system, and special lymphocytes from the adaptive system to destroy the antigen-antibody clumps.
  • Short-term: to keep you healthy
  • Long-term: adds to the overall immunity ACTIVE AND PASSIVE HUMORAL IMMUNITY The humoral response allows the body to achieve immunity by encountering pathogens either randomly or on purpose. ACTIVE HUMORAL IMMUNITY
  • When B cells bump into antigens and start producing antibodies.
  • Can occur naturally – catching flu or chickenpox
  • Occur artificially – through vaccination HOW VACCINES WORK
  • Vaccines are made up of dead or extremely weakened pathogen. By introducing a pathogen into your body, you’re priming it to fight hard and fast if that antigen shows up again.
  • To non-fatal infections (cough, common flu) o Prevents severe symptoms
  • To serious diseases (polio, measles) o Life-saving
  • Acquired immunity doesn’t have to be active PASSIVE HUMORAL IMMUNITY
  • Babies naturally obtain this while still in the womb. They receive antibodies from their mothers through placenta and through breast milk
  • Protection is temporary because passively obtained antibodies don’t live long in their new body and can’t produce effector cells or memory cells
  • Acquired artificially by receiving exogenous antibodies from the plasma of an immune donor.

o A serum was made from the blood plasma of the person who has been infected and survived. o The antibodies helped defend the patients from the virus before their own active immunity could identify that particular antigen and start creating their own antibodies. CELL-MEDIATED RESPONSE

  • There are plenty of pathogens that quickly worm their way right inside your cells, where they’re safer from the humoral response and free to multiply as much as they’d like. T cells – these lymphocytes go after body cells that have been hijacked by pathogens.
  • Can cause inflammation
  • Activate macrophages
  • Get other T cells fired up
  • Regulate much of the immune response PROFESSIONAL ANTIGEN PRESENTING CELLS
  • The phagocyte breaks the pathogen into tiny molecules, then displays those broken bits in grooved proteins on its outer membrane. These proteins are called Major Histocompatibility Complexes (MCHs).
  • MHC 1 proteins o MHC 1 proteins present short chains of amino acids that are based on endogenous proteins – proteins synthesized inside that cell. o So, if a particular cell is healthy, the antigens on its MHC 1 tell roving immune cells that everything’s ok inside, nothing to see here. o But if the cell is, say, cancerous and it’s making abnormal proteins, then it’ll fix bits of those proteins to its MHC, which alerts immune cells that there’s a problem inside, and basically asks to be killed.
  • MHC 2 Proteins o Macrophages, dendritic cells, and B cells o The professionals o Proteins bind to fragments of exogenous antigens, like a virus that’s been engulfed, broken up, and displayed to get the attention of other cells. o Essential to the cellular immune response
  • T cells, can’t actually detect whole antigens. They can only recognize them when they’re all diced up and decorating an antigen-presenting cell.
  • Made in the bone marrow, but they mature in the thymus, the lymphoid gland that sits on top your heart, and which is actually what the “T” in “T cell” stands for. HELPER T CELLS Helper Ts themselves can’t kill, but they can activate cells that do, and they help call the shots for the whole adaptive immune response.
  • Helper T cell has receptors that will only bind to one specific combination of a class 2 MHC and a particular antigen. If that match is right, the Helper T bonds to the MHC-antigen bit and it gets activated.
  • Helper T starts copying itself, making a few memory T cells as well, which remember that particular antigen should it meet one again in the future.
  • it also produces a whole mess of effector T cells, mostly more Helper Ts, but also some regulatory T cells The main thing the helper T cells do is raise the alarm that tells other immune cells that there is a problem.
  • Do this by releasing CYTOKINES , a cocktail of chemical messengers
  • When a cytokine enters another Helper T, that cell usually starts dividing, making more memory T cells and more Helper Ts, which release more cytokines that keep boosting the signal. And some of those cytokines also go on to help activate the cytotoxic T cells. CYTOTOXIC T CELLS Cytotoxic cells are the ones that actually do the killing of the cells gone bad.
  • They roam the blood and lymph, looking for infected amateur body cells that are asking to be killed.
  • If a cytotoxic T cell with the right receptor floats by, it binds to the antigen-MHC combination, and moves in for a mercy killing. It does this by releasing special enzymes that punch holes in the cell’s membrane or otherwise trigger apoptosis, killing