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Liver: Anatomy and Physiology, Pathophysiology, Study notes of Medicine

Far Eastern University (FEU)Medicine

The notes is about the role of the liver in the human body and the disease and conditions associated with it.

Typology: Study notes

2022/2023

Available from 02/13/2023

Xixiluciaa
Xixiluciaa 🇵🇭

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bg1
LIVER
4)
Excretory
/
secretory
•
major
metabolic
&
synthetic
processes
functions
•
versatile
/
major
organ
5.)
storage
•
hepatic
lobules
C
,
L
,
M
,
H
,
P
•
regenerative
capacity
→
can
recover
BILE
:
3-4
Ltd
;
it
is
used
*
capacity
is
only
up
to
≤
20%
lipid
digestion
FUNcM0N-
1)
metabolic
processes
a
C.
L
,
M
,
P
,
H
✗
BILE
HELPS
→
dietary
a
synthetic
lipid
-
synthesizes
clotting
factors
↓
emulsification
-
plasma
proteins
hydrolyse
TAG
3)
detoxification
-
urea
cycle
→
ammonia
A
bite
acids
>
MA
attach
>
waste
prod
.
-
macrophages
:
knpffer
cells
:
phagocytosis
during
config
.
of
Chile
.
M
.
2)
bile
salt
→
conjugated
in
liver
pf3
pf4
pf5

Partial preview of the text

Download Liver: Anatomy and Physiology, Pathophysiology and more Study notes Medicine in PDF only on Docsity!

LIVER 4)^ Excretory /^ secretory

  • major metabolic & (^) synthetic processes functions
  • versatile (^) /

major organ 5.) storage

  • hepatic lobules C ,

L , M , H^ ,^ P

regenerative capacity

→ (^) can (^) recover BILE :^ 3-4 Ltd ; it^ is used

  • (^) capacity is^

only up

to ≤ (^) 20% FUNcM0N- 1)^ metabolic^ processes^ lipid^ digestion a C. L^ ,^ M^ , P^ , H^ ✗

BILE HELPS

→ (^) dietary a (^) synthetic (^) lipid

synthesizes clotting^ factors^ ↓ emulsification

  • plasma proteins^ hydrolyse

TAG

  1. (^) detoxification
  • urea (^) cycle

→ ammonia A bite acids

> MA attach

waste prod.

  • macrophages :

knpffer cells^

: (^) phagocytosis during (^) config

.^ of^ Chile^.^ M^.

  1. (^) bile salt^ →^ conjugated^ in liver

Classifications (^) of Bite^ acids^ &^ bite^ salts^ ①^ Proto^ porphyrin^ Ix ① PRIMARY (^) @ SECONDARY

  • should be eliminated "" '""→ " "^ "" """

""" " "%

NF OF INTESTINES - Ex :
HEME
  • deoxydneeic - cannot be^ recycled ×.

litho chalice^ _

cyclic (^) STRUCTURE

  • chaotic opens up^4 changes
  • chemo

deoxy

chalice • ursodeoxychotic occur

BILIRUBIN ② BIUVERDTN

  • metabolic breakdown^ of heme^ ( (^250) -350mg / d) → greenish

BNvEbDW

③ (^) B

]gREDhctA

(^85) -90%

Kgb

to -^15 %^ myoglobin

  • unconjngated bilirubin

water (^) insoluble ( NP^ )

  • indirect (^) bilirubin
  • not excreted in (^) the urine
  • URINE : - 131

& - PLASMA : ✓ 131

LIVER DISORDERS^ b.^ cirrhosis^ : alcoholism

a. (^) jaundice c. (^) hepatitis

  • manifestation d.^ BO
  • yellow discoloration e.^ tumor f. (^) hepatic
  • skin (^) / sclera encelopathg 3-

my 1dL^

9.^ drug^ -^ dlohol^ related

DEPOSITION :^ Pre^ - hepatic ADULT :^ LESS^ HARMFUL ↑ BI

  • intact BBB Hepatic NEWBORN! FATAL ↑ (^) B
  • (^) ✗ intact^ BBB^ ( 15

-20mg 1dL^ )

Post
B

cos ↓ (^) Hepatic Jaundice kerniclems €^ mental retardation

light

  • _ (^) ↓ (^) biti ①

(^) MOTOR Physiology^ Jaundice^ of^ NB

DYSFUNCTION

( permanent)

↑ -^ immature^ liver

PH0totAERn

  • tight sensitive -^3 days

↑ B^ '

② CRIGLER - NAJJAR SYNDROME ⑤ ROTOR SYNDROME

genetic

  • viral infection
  • bilirubin

excretion

* UGT

lag ⁿ8upgpt -^ ↑^ B2 PLASMA (gene)

  • conjugation is detective
  • fatal - ↑B ③ (^) GILBERT (^) SYNDROME

acquired

  • detect in bilirubin (^) transport
  • ⑤ Hepatocytes

④ DUBIN^

  • JOHNSON^ →^ dark^ pigmentation ( (^) deposition of
  • (^) Genetic
HPO FUCHSIN )
  • emo - AT PROTEIN _ A N 4 L^ R (^) N (^) R ↑ (^) BI A (^) T G^1 A L e^ A^ O^ W ' (^) S^ N^ N c p^ I^ 5

4 E^ C^ Po

l (^) f R AR (^) F T E i r