CSO Exam: Interactions with Cancer Medications -
Appendix 8- questions with complete solutions
Bortezomib - correct answer(Velcade)
IV or SQ
-green tea should be avoided while taking this drug, especially in liquid and capsule
forms
-CYP3A4 inhibitors or inducers may alter drug activity, monitor closely
Capecitabine - correct answerXeloda
Oral directions: take within 30 mins of a mealw/full glass of water
-altered coagulation when taken with Warfarin, monitor closely
-Vitamin B6 (50-100mg 2-3x/day) may help to prevent/reduce the incidence and severity
of foot/hand syndrome
Cetuximab - correct answerErbitux
IV
-monitor serum mag and calcium levels closely
-at risk populations: elderly, hypomagnesia at baseline, pts who have received prior tx
w/oxaliplatin
Cisplatin - correct answerPlatinol
IV
-rigorous hydration is necessary to prevent nephrotoxicity
-carefully monitor renal function (BUN and Cr) and serum electrolytes (Mg, Ca, Na, K)
levels closely
-at risk populations: elderly, hypomag or those w/impaired renal function at baseline
cyclophosphamide - correct answerCytoxan
IV or oral
Oral: take preferably earlier in the day and w/vigorous hydration throughout the day
-advise vigorous oral hydration (3L/day)
-instruct pts to empty bladder every 2-3 hours during waking hours
-Mesna is given with high-dose cyclophosphamide to prevent hemorrhagic cystitis
-increases the effect of anticoagulants, so dose may need to be decreased
Dasatinib - correct answerSprycel
Oral: take with or w/o food
-avoid CYP3A4 inducers which may decrease drug activity (St. John's Wort,
phenobarbital)
