Cell Cycle Markers
The cell cycle refers to the whole process that the cell undergoes from the
completion of one split to the end of the next split and is divided into two phases:
the interphase and the split phase. Life is a continuous process that passes from one
generation to the next, so it is a process of constantly updating. The life of a cell
begins with the division of its parent cell, the formation of its daughter cells, or the
death of the cell itself. The formation of daughter cells is usually a sign of the end of
a cell division, which refers to the process that occurs from the time when a cell
divides to form a daughter cell until the next cell divides to form a daughter cell. In
this process, the genetic material of the cell is replicated and equally distributed to
the two daughter cells. In recent years, cell cycle markers such as minichromosome
maintenance protein, geminin, cyclinB1 and serine 10 phosphorylation histone 3
have become hotspots in the research of diseases such as tumors.
Cell cycle markers family members and their functions respectively
Minichromosome maintenance protein (MCM) is a family of highly conserved
proteins originally discovered in yeast. Its members include MCM2, MCM3, MCM4
(CDC54), MCM5, MCM6 (MIS5), MCM7 (CDC47), etc. These proteins can act as a DNA
replication regulator, so it is a molecule necessary for eukaryotic DNA replication.
Members of the MCM protein family have different structural compositions, but each
has a characteristic ATPase region of approximately 200 amino acid sequences. In
addition, MCM2, MCM4, MCM6, and MCM7 also contain a zinc finger region that
plays an important role between DNA and protein. The expression of MCM in cells is
periodic. When cells enter the G0 phase, most of MCM is not expressed, or its
expression level is the lowest.
