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Chapter 11: Kaposi Sarcoma and Vascular Anomalies, Exercises of Pathology

Acadia Divinity CollegePathology

Two topics: kaposi sarcoma and vascular anomalies. Kaposi sarcoma is discussed in detail, including its four forms based on demographics and risk, the implicated virus, the proteins produced by the virus, the three stages of cutaneous lesions, and histologic features. Vascular anomalies are also explained, with a focus on three types: developmental or berry aneurysms, arteriovenous fistulas, and fibromuscular dysplasia, along with their medical consequences.

Typology: Exercises

2017/2018

Uploaded on 05/09/2018

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Chapter 11 – Blood vessels
Kaposi sarcoma.
A) What are the four recognized forms of Kaposi sarcoma based on the
population demographics and risk? (4 marks)
1.
pf3

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Chapter 11 – Blood vessels

Kaposi sarcoma.

A) What are the four recognized forms of Kaposi sarcoma based on the population demographics and risk? (4 marks)

  2. Classic

  3. Endemic African

  4. Transplant associate

  5. (^) Epidemic (AIDS -associated)

B) What virus is implicated in the pathogenesis of Kaposi sarcoma? ( mark)

  • HHV 8-human herpes virus 8

C) What are two proteins produced by this virus that disrupt the normal cell proliferation and apoptosis? (2 mark)

  1. viral interleukin-6 (vIL-6),
    1. viral chemokines (vCCLs),
  2. viral G protein–coupled receptor (vGPCR),

D. What are the three stages of progress of cutaneous lesions in classic Kaposi sarcoma. (3 marks)

  1. patches
  2. raised plaques
  3. nodule

E. List three histologic features of Kaposi sarcoma. (1.5 marks)

  1. Sheets of plump spindle cells with small vessels/slit like spaces
  2. Extravasation of erythrocytes / hemorrhage
  3. Plasma cells/chronic inflammatory infiltrate
    • mitotic figures, round, pink, cytoplasmic globules