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The different types of toxic agents and their effects on human and animal health. It also explains the different types of responses to chemical exposure, including acute and chronic effects. The document highlights the top five toxic substances in terms of human and environmental health, as listed by the EPA in 2004. It also discusses the limitations of estimating toxicity levels and risks, including the fact that only a small percentage of registered synthetic chemicals have been thoroughly screened for toxicity.
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The damage to health resulting from exposure to a chemical is called response. Acute effect is an immediate or rapid harmful reaction ranging from dizziness and nausea to death. Chronic effect is a permanent or long-lasting consequence (Kidney or liver damage, for example) of exposure to a single dose or to repeated lower doses of a harmful substance. Case reports provide information about people suffering some adverse health effect or death after exposure to a chemical. Epidemiological studies, which compare the health of people exposed to a particular chemical (the experimental group) with the health of a similar group of people not exposed to the agent (the control group), but limited by: Too few people have been exposed to high enough levels of a toxic agent to detect statistically significant differences. CHEMICAL HAZARD