"Patients can use up to 2000 mg of Acetaminophen every day and is considerably not an overdose. Hepatotoxicity from a single overdose occurs at 15 grams and usage of over 2000 mg each day over a period of time can turn out to be harmful too. However, a dosage of 1000 mg every day by patients with weak livers is sufficient enough to cause liver damage at some point as well. If you really need to take that amount of acetaminophen each day, then I suggest to you to take Liver function tests once every month, just to be on the safe side. Good Health!"